Hydrogen chloride-ethyl acetate → HCID 86684890, compound

HRID 238394Notes

Reaction equation

HRID 238394 reaction equation
[CH3:1][N:2]([CH3:33])[CH2:3][CH2:4][NH:5][S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]#[C:16][C:17]2[CH:18]=[N:19][N:20]([CH3:32])[C:21]=2[C:22]2[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=2)[CH:10]=1)(=[O:8])=[O:7].[ClH:34].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:34].[CH3:33][N:2]([CH3:1])[CH2:3][CH2:4][NH:5][S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]#[C:16][C:17]2[CH:18]=[N:19][N:20]([CH3:32])[C:21]=2[C:22]2[CH:23]=[CH:24][C:25]([C:28]([F:29])([F:30])[F:31])=[CH:26][CH:27]=2)[CH:10]=1)(=[O:7])=[O:8]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 56642481HCID 56642481, compound

Product 1

HCID 86684890HCID 86684890, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To an ethyl acetate (0.76 mL) solution of the N-[2-(dimethylamino)ethyl]-3-({1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl}ethynyl)benzenesulfonamide (76 mg) obtained in Example 1, a 4 M HCl/ethyl acetate solution (48 μL) was added at a room temperature, and the obtained solution was then stirred for 3 hours. Thereafter, the generated solid was collected by filtration, and was then washed with ethyl acetate, so as to obtain the title compound (58 mg) in the form of a colorless solid.

Workup

  1. filtrationThereafter, the generated solid was collected by filtration
  2. washwas then washed with ethyl acetate

Sources & evidence

ORD record
ord-faccb74a579645d2a17a46b6f4c7aec6
Source dataset
uspto-grants-2014_02
Patent number
US08642626B2

Reaction notes

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