反应详情

温度

75 °C

A mixture of the compound obtained in example 6 (100 mg, 0.267 mmol), guanidine HCl (33.5 mg, 0.35 mmol) and sodium ethoxide (25 mg, 0.35 mmol) in 5 ml ethanol was heated at 70-80° C. for 1 hr. The mixture was cooled to room temperature and the solvent was evaporated under vacuum. The crude residue was purified by column chromatography to get 80 mg (81% yields) of a white colored solid product.

1. temperatureThe mixture was cooled to room temperature
2. customthe solvent was evaporated under vacuum
3. customThe crude residue was purified by column chromatography
4. customto get
5. custom80 mg (81% yields) of a white colored solid product