HCID 58297375, compound → HCID 58297373, compound

HRID 238414Notes

Reaction equation

HRID 238414 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]([CH2:22][CH2:23][NH:24]C(=O)OC(C)(C)C)[CH:11]=[CH:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)=[C:5]([CH3:32])[CH:4]=1)#[N:2]>Cl>[NH2:24][CH2:23][CH2:22][N:10]1[CH:11]=[CH:12][C:13]([C:14]2[CH:15]=[CH:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=2)=[C:9]1[C:6]1[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][C:5]=1[CH3:32]

Participants

3

Reactant 1

HCID 58297375HCID 58297375, compound

Product 1

HCID 58297373HCID 58297373, compoundYield 118.3%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of tert-butyl 2-(2-(4-cyano-2-methylphenyl)-3-(4-methoxyphenyl)-1H-pyrrol-1-yl)ethylcarbamate (6-1) (110 mg, 0.255 mmol) in methanolic hydrochloride solution (2 M, 5 mL) was stirred at room temperature for 1 hour. The mixture was concentrated in vacuo to give the title compound 6-2 (100 mg), which was used directly in the next step.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-ff93f1ec12d74732a41dab33ae24f918
Source dataset
uspto-grants-2014_02
Patent number
US08642628B2

Reaction notes

Loading…