反应详情

2,2-Dimethyl-6-nitro-4H-benzo[1,4]oxazin-3-one (1.1 g) was mixed with MeI (850 mg, Aldrich), K2CO3 (1.38 g, Aldrich) and DMF (30 ml, Aldrich) at 40° C. for 48 h. The DMF was removed in vacuo and the residue was diluted with EtOAc (80 ml). The organic phase was washed with H2O (50 ml), aqueous Na2SO3 (50 ml) and brine (50 ml). The resulting solution was dried (MgSO4) and concentrated to provide the compound which was used as is.

1. customThe DMF was removed in vacuo
2. additionthe residue was diluted with EtOAc (80 ml)
3. washThe organic phase was washed with H2O (50 ml), aqueous Na2SO3 (50 ml) and brine (50 ml)
4. dry with materialThe resulting solution was dried (MgSO4)
5. concentrationconcentrated
6. customto provide the compound which