Hydrochloric Acid → HCID 24803739, compound

HRID 2384923Notes

Reaction equation

HRID 2384923 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:33][C:11]3[C:12](=[O:32])[N:13]([C:16]4[CH:21]=[CH:20][C:19]([N:22]5[CH2:26][CH2:25][C@H:24]([N:27]([CH3:29])[CH3:28])[CH2:23]5)=[C:18]([O:30][CH3:31])[CH:17]=4)[CH:14]=[CH:15][C:10]=3[CH:9]=2)=[CH:4][CH:3]=1.Cl.CCOCC>ClCCl.CO.CCO>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:33][C:11]3[C:12](=[O:32])[N:13]([C:16]4[CH:21]=[CH:20][C:19]([N:22]5[CH2:26][CH2:25][C@H:24]([N:27]([CH3:28])[CH3:29])[CH2:23]5)=[C:18]([O:30][CH3:31])[CH:17]=4)[CH:14]=[CH:15][C:10]=3[CH:9]=2)=[CH:4][CH:3]=1

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 24803740HCID 24803740, compound

Product 1

HCID 24803739HCID 24803739, compoundYield 79%

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

Prepare the HCl salt by dissolving the free base in dichloromethane and MeOH. Treat the mixture with 1.0 M HCl in EtOH, add Et2O, filter, and wash with Et2O. Dry in a vacuum oven at RT for 2 days to give 0.249 g (79%) of the title compound. LC-MS/ES m/z (35Cl) 480.2 [M+H]+.

Workup

  1. filtrationfilter
  2. washwash with Et2O
  3. customDry in a vacuum oven at RT for 2 days

Sources & evidence

ORD record
ord-319f7292d75e47319eb1f815a299277c
Source dataset
uspto-grants-2012_09
Patent number
US08263772B2

Reaction notes

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