反应详情

A solution of 2,6-difluoropyridine-3-carboxylic acid (3.2 g, 20 mmol), t-butylaniline (3.0 g, 20 mmol), HOBt (2.6 g, 20 mmol), EDAC (8 g, 40 mmol), and DIEA (8 mL) in CH2Cl2 (80 mL) was stirred at RT for 1 h. The mixture was washed with aq. NaHCO3 and brine. The organic solution was dried over Na2SO4 and concentrated in vacuo. The residue was purified via flash chromatography on silica (Hex:EtOAc=4:1) to give a light yellow flaky crystal as desired product.

1. washThe mixture was washed with aq. NaHCO3 and brine
2. dry with materialThe organic solution was dried over Na2SO4
3. concentrationconcentrated in vacuo
4. customThe residue was purified via flash chromatography on silica (Hex:EtOAc=4:1)