反应详情

温度

60 °C

A mixture of 50 g (475.56 mmol) of 2-(2-amino-ethoxy)ethanol and 144.6 g (1.046 mol) of potassium carbonate in 600 ml of EtOH/60 ml of water is heated to 60° C. To this mixture is added dropwise within one hour 178.95 g (1.046 mol) of benzyl bromide and then the mixture is refluxed for 2 hours, evaporated under vacuum, the residue taken up with 1 liter of methylene chloride, and filtered off from the salts. The filtrate is concentrated under vacuum and purified by flash chromatography (silica gel/mobile phase: methylene chloride/hexane/acetone: 10/5/1).

1. temperaturethe mixture is refluxed for 2 hours
2. customevaporated under vacuum
3. filtrationfiltered off from the salts
4. concentrationThe filtrate is concentrated under vacuum
5. custompurified by flash chromatography (silica gel/mobile phase: methylene chloride/hexane/acetone: 10/5/1)