反应详情

A solution of potassium hydroxide (11.0 g, 196 mmol, 50%) in water was added to a suspension of 2,5-bis-ethanesulfonyl-pyridine (12.0 g, 45.6 mmol, prepared using the method described above) in water and tetrahydrofuran (100 mL, 1:1, v/v). After being heated at reflux for 1 hour, the mixture was acidified with 0.5 N hydrochloric acid to pH 3 and concentrated in vacuo to remove the solvent. The residue was triturated with boiling ethanol (150 mL) and filtered. The filtrates were concentrated in vacuo to afford the crude product which was used in the next step without further purification.

1. customprepared
2. temperatureAfter being heated
3. temperatureat reflux for 1 hour
4. concentrationconcentrated in vacuo
5. customto remove the solvent
6. customThe residue was triturated with boiling ethanol (150 mL)
7. filtrationfiltered
8. concentrationThe filtrates were concentrated in vacuo