2-Amino-2-methyl-1-propanol → HCID 77174800, compound

HRID 2385877Notes

Reaction equation

[NH2:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4].[C:7]([N:15]=[C:16]=[S:17])(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[OH:4][CH2:3][C:2]([NH:1][C:16]([NH:15][C:7](=[O:14])[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)=[S:17])([CH3:6])[CH3:5]

Participants

Reactant 2

HCID 118072-Amino-2-methyl-1-propanol

HCID 68284Benzoyl isothiocyanate

Product 1

HCID 77174800HCID 77174800, compound

Procedure

Following the procedure in US2008/45579, 2008, 2-amino-2-methylpropan-1-ol was coupled with benzoylisothiocyanate to give N-(1-hydroxy-2-methylpropan-2-ylcarbamothioyl)benzamide which was then reacted with lithium hydroxide to give 1-(1-hydroxy-2-methylpropan-2-yl)thiourea. 1H NMR (400 MHz, DMSO) δ 7.09 (s, 2H), 5.01 (s, 1H), 3.44 (s, 2H), 1.30 (s, 6H)

Sources & evidence

ORD record: ord-1ee39616d578454b8a9e6fa1a0a0a489
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08263633B2

Reaction notes

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