Hydrochloric Acid → HCID 18440640, compound

HRID 2387251Notes

Reaction equation

HRID 2387251 reaction equation
N[C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[N:11]1C=CC=CC=1.[F:17][C:18]1[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=1[C:20](Cl)=[O:21].Cl>C(Cl)(Cl)Cl>[F:17][C:18]1[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=1[C:20]([C:2]1[C:10]([NH2:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5])=[O:21]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 6942AnthranilamideHCID 98082-Fluorobenzoyl chloride

Product 1

HCID 18440640HCID 18440640, compoundYield 82.7%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
0 °C

Procedure

2-Amino-benzamide (1 g, 7.3 mmol) was dissolved in chloroform (25 ml) in a 50 ml round bottomed flask and cooled to 0° C. Pyridine (0.6 ml, 7.3 mmol) was added followed by 2-fluoro-benzoyl chloride (1 ml, 8 mmol) and the mixture was magnetically stirred for 1 hr at this temperature. 10% Hydrochloric acid (50 ml) was added and the precipitated solid was filtered, washed with water and dried to yield pure title compound (1.56 g, 82%).

Workup

  1. filtrationthe precipitated solid was filtered
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-e1835b5afbe5438282c47626c75c24dd
Source dataset
uspto-grants-2012_09
Patent number
US08268857B2

Reaction notes

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