反应详情

To a solution of the product from step (ix) (57 mg) in THF (5 mL) was added (4-formylphenyl)acetic acid methyl ester (51 mg) and acetic acid (0.011 mL). The resulting mixture was stirred for 5 h, sodium triacetoxyborohydride (90 mg) was added and the resulting solution stirred at rt for 16 h. TEA (0.013 mL) was added and the reaction mixture stirred for a further 2 h. The solvents were evaporated, the residue redissolved in MeOH and purified by RPHPLC to afford the title compound 2.7 mg.

1. stirringthe resulting solution stirred at rt for 16 h
2. stirringthe reaction mixture stirred for a further 2 h
3. customThe solvents were evaporated
4. dissolutionthe residue redissolved in MeOH
5. custompurified by RPHPLC