Potassium Cyanide → HCID 178433372, compound

HRID 2387857Notes

Reaction equation

HRID 2387857 reaction equation
[C-:1]#[N:2].[K+].Cl.[NH2:5][C:6]1[N:11]=[C:10]([OH:12])[C:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20]Cl)=[CH:16][CH:15]=2)=[C:8]([CH3:22])[N:7]=1>CN(C=O)C.CS(C)=O>[NH2:5][C:6]1[N:11]=[C:10]([OH:12])[C:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:1]#[N:2])=[CH:16][CH:15]=2)=[C:8]([CH3:22])[N:7]=1

Participants

5

Reactant 2

HCID 9032Potassium CyanideHCID 178433371HCID 178433371, compound

Product 1

HCID 178433372HCID 178433372, compound

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 6228DimethylformamideSolvent

Procedure

Potassium cyanide (2 g) was added to a solution of the product from step (ii) in DMF (20 ml) and DMSO (10 ml) and the mixture stirred at rt for 18 h. The mixture was flushed with nitrogen for 20 min, then diluted with brine (80 ml), stirred for 10 min and the precipitate filtered, washed with water then ether and dried to afford the subtitle compound, 2.46 g.

Workup

  1. customThe mixture was flushed with nitrogen for 20 min
  2. additiondiluted with brine (80 ml)
  3. stirringstirred for 10 min
  4. filtrationthe precipitate filtered
  5. washwashed with water
  6. dry with materialether and dried

Sources & evidence

ORD record
ord-a6d2c18a1c3a4611bf1fb6db3b0a190f
Source dataset
uspto-grants-2012_09
Patent number
US08268990B2

Reaction notes

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