HCID 86633412, compound → HCID 42613547, compound

HRID 2387872Notes

Reaction equation

HRID 2387872 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([O:19][CH2:20][CH:21]3[CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23][CH2:22]3)=[O:18])=[CH:12][CH:11]=2)=[C:4]([NH:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])[N:3]=1>C(Cl)Cl.C(O)(C(F)(F)F)=O>[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][C:10]2[CH:11]=[CH:12][C:13]([CH2:16][C:17]([O:19][CH2:20][CH:21]3[CH2:22][CH2:23][NH:24][CH2:25][CH2:26]3)=[O:18])=[CH:14][CH:15]=2)=[C:4]([NH:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])[N:3]=1

Participants

4

Reactant 1

HCID 86633412HCID 86633412, compound

Product 1

HCID 42613547HCID 42613547, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

To the product of step (i) (237 mg) in DCM (7 ml), TFA (2 ml) was added and stirred at rt for 7 h. The solvent was removed and the crude product was partitioned between DCM/NaHCO3 (aq), dried and evaporated under reduced pressure. The residue was purified by RPHPLC to give a white solid, 54 mg.

Workup

  1. customThe solvent was removed
  2. customthe crude product was partitioned between DCM/NaHCO3 (aq)
  3. customdried
  4. customevaporated under reduced pressure
  5. customThe residue was purified by RPHPLC
  6. customto give a white solid, 54 mg

Sources & evidence

ORD record
ord-6f8245381f77494fbdfb324121714d8f
Source dataset
uspto-grants-2012_09
Patent number
US08268990B2

Reaction notes

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