Hydrochloric Acid → HCID 178433379, compound

HRID 2387905Notes

Reaction equation

HRID 2387905 reaction equation
[SH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][CH:3]=1.[NH2:10][C:11]1[N:16]=[C:15]([OH:17])[C:14](Br)=[C:13]([CH3:19])[N:12]=1.C([O-])([O-])=O.[K+].[K+].Cl>C(O)CO.O>[NH2:10][C:11]1[N:16]=[C:15]([OH:17])[C:14]([S:1][C:2]2[CH:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][CH:3]=2)=[C:13]([CH3:19])[N:12]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 4677905(4-Sulfanylphenyl)methanolHCID 1784333692-amino-5-bromo-6-methyl-1H-pyrimidin-4-one

Product 1

HCID 178433379HCID 178433379, compound

Reagents, catalysts & solvents 2

HCID 174Ethylene GlycolSolventHCID 962WaterSolvent

Conditions

Temperature
155 °C

Procedure

A stirred mixture of (4-mercaptophenyl)methanol (6.72 g), 2-amino-5-bromo-6-methylpyrimidin-4-ol (10.76 g) and K2CO3 (7.29 g) in ethylene glycol (120 ml) was heated at 155° C. for 9 h. After cooling the mixture was poured into water (500 ml) and neutralised with conc. HCl. The precipitate was filtered, washed with water then 50% EtOH/ether and dried to give the subtitle compound as a solid, 6.7 g.

Workup

  1. temperatureAfter cooling the mixture
  2. filtrationThe precipitate was filtered
  3. washwashed with water
  4. dry with material50% EtOH/ether and dried

Sources & evidence

ORD record
ord-40b53214b66a4af5860f290ae1e1e68e
Source dataset
uspto-grants-2012_09
Patent number
US08268990B2

Reaction notes

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