Trifluoroacetic acid → HCID 59367776, compound

HRID 2387942Notes

Reaction equation

HRID 2387942 reaction equation
C(OC([N:8]1[CH2:32][CH2:31][C:11]2([CH2:16][CH2:15][C:14]([C:25]3[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=3)([O:17][CH2:18][CH2:19][N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)[CH2:13][CH2:12]2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[N:27]1[CH:28]=[CH:29][CH:30]=[C:25]([C:14]2([O:17][CH2:18][CH2:19][N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)[CH2:13][CH2:12][C:11]3([CH2:31][CH2:32][NH:8][CH2:9][CH2:10]3)[CH2:16][CH2:15]2)[CH:26]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67356290HCID 67356290, compound

Product 1

HCID 59367776HCID 59367776, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

3-Pyridin-3-yl-3-(2-pyrrolidin-1-yl-ethoxy)-9-azaspiro[5.5]undecane-9-carboxylic acid tert-butyl ester (0.282 mmol, 1 equiv.) was dissolved in DCM (3 ml). At 0° C., trifluoroacetic acid (1.5 ml) was added, and the mixture was stirred for 2 hours at 25° C. The solvent was concentrated under reduced pressure and the residue was taken up in DCM (2×10 ml) and dried to yield the desired product.

Workup

  1. concentrationThe solvent was concentrated under reduced pressure
  2. customdried

Sources & evidence

ORD record
ord-25a3f0c666944dac9ac35fa8a6ab29c7
Source dataset
uspto-grants-2012_09
Patent number
US08269000B2

Reaction notes

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