Hydrochloric Acid → HCID 59541821, compound

HRID 2388358Notes

Reaction equation

HRID 2388358 reaction equation
O1[C:5]2([CH2:10][CH2:9][CH:8]([C:11]3[N:19]=[C:14]4[CH2:15][CH2:16][CH2:17][CH2:18][N:13]4[N:12]=3)[CH2:7][CH2:6]2)[O:4]CC1.Cl>CC#N>[N:19]1[C:11]([CH:8]2[CH2:7][CH2:6][C:5](=[O:4])[CH2:10][CH2:9]2)=[N:12][N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][C:14]=12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66750816HCID 66750816, compound

Product 1

HCID 59541821HCID 59541821, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 2-(1,4-dioxa-spiro[4.5]dec-8-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine (1.05 g, 4 mmol, prepared according to the literature procedure: Quanrui Wang, Atef Amer, Susanne Mohr, Eveline Ertel, Johannes C. Jochims, Tetrahedron, 1993, 49(44), 9973-9986) in CH3CN (20 mL) and 2N HCl (30 mL) was stirred at rt for 2 h. Evaporation to dryness gave the intermediate as a HCl salt.

Workup

  1. customEvaporation to dryness

Sources & evidence

ORD record
ord-c186512e301f4bfab0b18801ff0b0916
Source dataset
uspto-grants-2012_09
Patent number
US08269015B2

Reaction notes

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