Trifluoroacetic acid → HCID 57948664, compound

HRID 2388668Notes

Reaction equation

HRID 2388668 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]2[CH2:17][CH2:16][CH2:15][C@H:14]2[CH2:18][O:19][CH2:20][C:21]([O:23]C(C)(C)C)=[O:22])(=[O:12])=[O:11])=[C:5]([CH3:28])[CH:4]=1.FC(F)(F)C(O)=O>ClCCl>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]2[CH2:17][CH2:16][CH2:15][C@H:14]2[CH2:18][O:19][CH2:20][C:21]([OH:23])=[O:22])(=[O:12])=[O:11])=[C:5]([CH3:28])[CH:4]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68643973HCID 68643973, compound

Product 1

HCID 57948664HCID 57948664, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of (S)-tert-butyl 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)-pyrrolidin-2-yl)methoxy)acetate (1 eq.) in dichloromethane (10 ml/mmol) was added trifluoroacetic acid (2 ml/mmol) at 0° C. and the resulting reaction mixture was stirred at 25° C. for 2 h. The solvent was evaporated off and it was dried under vacuum to remove traces of trifluoroacetic acid. The crude product was used directly for the next step. Yield: quantitative.

Workup

  1. customthe resulting reaction mixture
  2. customThe solvent was evaporated off
  3. customit was dried under vacuum
  4. customto remove traces of trifluoroacetic acid

Sources & evidence

ORD record
ord-923f4336e0e6430281ae31395532d477
Source dataset
uspto-grants-2012_09
Patent number
US08268814B2

Reaction notes

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