Lithium hydroxide, monohydrate → HCID 68644004, compound

HRID 2388704Notes

Reaction equation

HRID 2388704 reaction equation
[C:1]1([CH:7]2[C:12]3[C:13]([C:16]([O:18]CC)=[O:17])=[N:14][O:15][C:11]=3[CH2:10][CH2:9][N:8]2[C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O[Li].O>C(O)C.O>[C:24]([O:23][C:21]([N:8]1[CH2:9][CH2:10][C:11]2[O:15][N:14]=[C:13]([C:16]([OH:18])=[O:17])[C:12]=2[CH:7]1[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[O:22])([CH3:27])([CH3:25])[CH3:26]

Participants

4

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 68644058HCID 68644058, compound

Product 1

HCID 68644004HCID 68644004, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

5-tert-Butyl 3-ethyl 4-phenyl-6,7-dihydroisoxazolo[4,5-c]pyridine-3,5(4H)-dicarboxylate (1.75 mmol) was hydrolyzed to corresponding acid by using LiOH.H2O (1.5 eq.) as a base in ethanol-water (10 ml, 4:1). Yield: quantitative.

Sources & evidence

ORD record
ord-cbb239964d9c4d93b7fcf107c40aa365
Source dataset
uspto-grants-2012_09
Patent number
US08268814B2

Reaction notes

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