Trifluoroacetic acid → HCID 28293479, compound

HRID 2388711Notes

Reaction equation

HRID 2388711 reaction equation
[N:1]1([CH2:7][C:8]2[S:9][C:10]3[CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][CH2:14][C:15]=3[N:16]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.FC(F)(F)C(O)=O>ClCCl>[N:1]1([CH2:7][C:8]2[S:9][C:10]3[CH2:11][NH:12][CH2:13][CH2:14][C:15]=3[N:16]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68644070HCID 68644070, compound

Product 1

HCID 28293479HCID 28293479, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a cooled (0° C.) solution of tert-butyl 2-(piperidin-1-ylmethyl)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate (0.534 mmol) in dichloromethane (3 ml) was added trifluoroacetic acid (1 ml) and reaction mixture was stirred at room temperature for 2 h. Solvent was evaporated under reduced pressure and residue was azeotroped twice with dichloromethane and used in the next step.

Workup

  1. additionwas added
  2. customSolvent was evaporated under reduced pressure and residue
  3. customwas azeotroped twice with dichloromethane

Sources & evidence

ORD record
ord-54b9509cbd18448f9b95f25ec90d1251
Source dataset
uspto-grants-2012_09
Patent number
US08268814B2

Reaction notes

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