Sodium hydride → HCID 53628391, compound

HRID 2388846Notes

Reaction equation

HRID 2388846 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([S:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[C:12]=2[F:18])[N:3]=1.[Si:19]([O:26][CH2:27][C@H:28]([OH:34])[CH2:29][O:30][CH:31]([CH3:33])[CH3:32])([C:22]([CH3:25])([CH3:24])[CH3:23])([CH3:21])[CH3:20].[H-].[Na+]>C1COCC1>[Si:19]([O:26][CH2:27][C@@H:28]([CH2:29][O:30][CH:31]([CH3:33])[CH3:32])[O:34][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([S:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[C:12]=2[F:18])[N:3]=1)([C:22]([CH3:25])([CH3:24])[CH3:23])([CH3:21])[CH3:20]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 859280374,6-Dichloro-2-((2,3-difluorobenzyl)thio)pyrimidineHCID 86619886HCID 86619886, compound

Product 1

HCID 53628391HCID 53628391, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The subtitle compound was prepared according to the procedure outlined in example 1 step iii) using 4,6-Dichloro-2-[(2,3-difluorobenzyl)thio]pyrimidine (product of example 1 step ii) (0.46 g), (2R)-1-{[tert-butyl(dimethyl)silyl]oxy}-3-isopropoxypropan-2-ol (product of step (0.66 g), THF (5 mL) and 60% sodium hydride (80 mg), to give the subtitle compound as a colourless oil. Yield: 0.56 g

Workup

  1. customThe subtitle compound was prepared

Sources & evidence

ORD record
ord-af8b04fae58844d89dc5436f15dd7842
Source dataset
uspto-grants-2012_09
Patent number
US08269002B2

Reaction notes

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