Methanesulfonyl chloride → HCID 59558785, compound

HRID 2388885Notes

Reaction equation

HRID 2388885 reaction equation
[F:1][C:2]1[C:27]([F:28])=[CH:26][CH:25]=[CH:24][C:3]=1[CH2:4][S:5][C:6]1[N:11]=[C:10]([NH:12][S:13]([N:16]2[CH2:19][C:18](O)([CH3:20])[CH2:17]2)(=[O:15])=[O:14])[CH:9]=[C:8]([O:22][CH3:23])[N:7]=1.C([N:32](C(C)C)CC)(C)C.CS(Cl)(=O)=O>C1COCC1>[NH2:32][C:18]1([CH3:20])[CH2:19][N:16]([S:13]([NH:12][C:10]2[CH:9]=[C:8]([O:22][CH3:23])[N:7]=[C:6]([S:5][CH2:4][C:3]3[CH:24]=[CH:25][CH:26]=[C:27]([F:28])[C:2]=3[F:1])[N:11]=2)(=[O:15])=[O:14])[CH2:17]1

Participants

5

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 59558816HCID 59558816, compound2×

Product 1

HCID 59558785HCID 59558785, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of N-{2-[(2,3-difluorobenzyl)thio]-6-methoxypyrimidin-4-yl}-3-hydroxy-3-methylazetidine-1-sulfonamide (the product from example 129, 0.2 g) in THF (5 ml) was treated with diisopropylethylamine (0.45 ml) and methanesulfonylchloride (0.11 ml) under nitrogen.

Sources & evidence

ORD record
ord-e9054ba051304dd08460dac1a498a378
Source dataset
uspto-grants-2012_09
Patent number
US08269002B2

Reaction notes

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