反应详情

Procedure D was performed using 4-(methylsulfonyl)benzoic acid (102 mg, 0.49 mmol), EDC (186 mg, 0.93 mmol), DIPEA (0.16 ml, 0.93 mmol), 6-chloro-hydroxybenzotriazole (162 mg, 0.93 mmol) and aniline (119 mg, 0.46 mmol). The crude product was purified by flash column chromatography on silica gel eluting with EtOAc:hexanes (0:1 to 3:2) to afford the desired 4-chloro-3-quinoxalin-2-yl-phenylamine (104 mg, 0.24 mmol).

1. customThe crude product was purified by flash column chromatography on silica gel eluting with EtOAc:hexanes (0:1 to 3:2)