Hydrogen Peroxide → 5-(4-Bromophenyl)-1H-indole-3-carboxamide

HRID 2389265Notes

Reaction equation

HRID 2389265 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[NH:13][CH:12]=[C:11]3[C:17]#[N:18])=[CH:4][CH:3]=1.[OH:19]O.[OH-].[Na+]>C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[NH:13][CH:12]=[C:11]3[C:17]([NH2:18])=[O:19])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 59145397HCID 59145397, compound

Product 1

HCID 591454175-(4-Bromophenyl)-1H-indole-3-carboxamide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4 (1.00 g, 3.38 mmol) in ethanol was treated with hydrogen peroxide (30%) and 1N NaOH. On completion of reaction solvent was removed and the resultant solid was washed with organic solvents to give pure 5 as a beige colored solid.

Workup

  1. customOn completion of reaction solvent
  2. customwas removed
  3. washthe resultant solid was washed with organic solvents

Sources & evidence

ORD record
ord-28903cc526434bc8b434ac5b5234469d
Source dataset
uspto-grants-2012_09
Patent number
US08273744B2

Reaction notes

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