反应详情

To a solution of ethyl (3-{3-[(methylsulfonyl)oxy]propyl}phenoxy)acetate (155 g) in acetone (1.55 L) was added sodium iodide (293.7 g) at ambient temperature and the mixture was stirred at the same temperature for 18 hours. EtOAc (1 L) was added to the mixture at ambient temperature and the resulting mixture was washed successively with water and brine. The organic layer was dried over anhydrous MgSO4, filtered and evaporated in vacuo to afford ethyl [3-(3-iodopropyl)phenoxy]acetate (142 g) as a red oil.

1. washthe resulting mixture was washed successively with water and brine
2. dry with materialThe organic layer was dried over anhydrous MgSO4
3. filtrationfiltered
4. customevaporated in vacuo