Hydrogen chloride-ethyl acetate → HCID 68535442, compound

HRID 2389357Notes

Reaction equation

HRID 2389357 reaction equation
[C:1]([N:9]([CH2:20][CH2:21][CH:22]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:10][CH2:11][NH:12]C(=O)OC(C)(C)C)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:35].CCOC(C)=O>CCOC(C)=O.CCCCCC>[ClH:35].[NH2:12][CH2:11][CH2:10][N:9]([CH2:20][CH2:21][CH:22]([C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)[C:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86637910HCID 86637910, compound

Product 1

HCID 68535442HCID 68535442, compound

Reagents, catalysts & solvents 2

HCID 8058HexaneSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a suspension of tert-butyl {2-[benzoyl-(3,3-diphenylpropyl)amino]ethyl}carbamate (225 mg) in EtOAc (675 μL) was added 4M HCl/EtOAc (1.23 mL) at ambient temperature and the mixture was stirred at the same temperature for 1 hour. The resulting mixture was diluted with n-hexane (5.0 mL) and the precipitate was collected by filtration followed by washing with n-hexane (10 mL) to afford N-(2-aminoethyl)-N-(3,3-diphenylpropyl)benzamide hydrochloride (166 mg) as colorless crystals.

Workup

  1. filtrationthe precipitate was collected by filtration
  2. washby washing with n-hexane (10 mL)

Sources & evidence

ORD record
ord-a1a04c314aad429cbcb0f95eefa7a223
Source dataset
uspto-grants-2012_09
Patent number
US08273745B2

Reaction notes

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