反应详情

温度

60 °C

To a solution of 3-(3-hydroxypropyl)phenol (1.27 g) in MeCN (12.7 mL) were added K2CO3 (1.73 g) and benzyl bromide (1.05 mL) at ambient temperature and the mixture was stirred at 60° C. for 16 hours. Water (15 mL) was added to the mixture at ambient temperature and the resulting mixture was extracted with EtOAc (20 mL, two times). The organic layer was washed with brine, dried over anhydrous MgSO4, filtered and evaporated in vacuo. The residue was purified by silica gel column chromatography (n-hexane:EtOAc=3:1) to afford 3-[3-(benzyloxy)phenyl]-1-propanol (1.77 g) as a colorless oil.

1. extractionthe resulting mixture was extracted with EtOAc (20 mL, two times)
2. washThe organic layer was washed with brine
3. dry with materialdried over anhydrous MgSO4
4. filtrationfiltered
5. customevaporated in vacuo
6. customThe residue was purified by silica gel column chromatography (n-hexane:EtOAc=3:1)