反应详情

To a solution of 3-(2-hydroxyethyl)phenol (1.0 g) and K2CO3 (1.5 g) in acetone (20 mL) was added (bromomethyl)benzene (1.49 g) at ambient temperature. The reaction mixture was stirred at the same temperature for 17 hours. The resulting mixture was evaporated in vacuo. The residue was diluted with EtOAc and washed successively with water and brine. The organic layer was dried over anhydrous MgSO4, filtered and evaporated in vacuo. The residue was purified by silica gel column chromatography (n-hexane:EtOAc=90:10-70:30) to give 2-[3-(benzyloxy)phenyl]ethanol.

1. customThe resulting mixture was evaporated in vacuo
2. additionThe residue was diluted with EtOAc
3. washwashed successively with water and brine
4. dry with materialThe organic layer was dried over anhydrous MgSO4
5. filtrationfiltered
6. customevaporated in vacuo
7. customThe residue was purified by silica gel column chromatography (n-hexane:EtOAc=90:10-70:30)