2-Amino-2-methyl-1-propanol → HCID 178481268, compound

HRID 2389532Notes

Reaction equation

HRID 2389532 reaction equation
[CH2:1]([C:8]1[N:9]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:23][CH:22]=2)[N:10]=[C:11]2[C:16]=1[C:15](=[O:17])[N:14]([CH3:18])[C:13](Cl)=[N:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:33][C:34]([CH3:38])([CH3:37])[CH2:35][OH:36]>CN(C=O)C>[CH2:1]([C:8]1[N:9]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:23][CH:22]=2)[N:10]=[C:11]2[C:16]=1[C:15](=[O:17])[N:14]([CH3:18])[C:13](=[N:33][C:34]([CH3:38])([CH3:37])[CH2:35][OH:36])[NH:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 692418433-Benzyl-2-(biphenyl-4-ylmethyl)-6-chloro-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

Product 1

HCID 178481268HCID 178481268, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 3-Benzyl-2-(biphenyl-4-ylmethyl)-6-chloro-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (9.5 mg, 0.022 mmol) and 2-amino-2-methyl-1-propanol (21 μL, 0.22 mmol) in DMF (2 mL) is heated at 110° C. overnight. The reaction mixture is then purified by chromatography to give 5.5 mg product (Yield: 52%). MS (FAB) m/z 494.4 [M+H]+.

Workup

  1. customThe reaction mixture is then purified by chromatography

Sources & evidence

ORD record
ord-113c8becd98f4aacb21b78c1767125ad
Source dataset
uspto-grants-2012_09
Patent number
US08273750B2

Reaction notes

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