Hydrochloric Acid → HCID 59400108, compound

HRID 2389554Notes

Reaction equation

HRID 2389554 reaction equation
[C:1]1([S:7]([N:10]2[CH2:16][CH2:15][CH:14]([NH:17]C(=O)OC(C)(C)C)[CH2:13][C:12]3[CH:25]=[CH:26][CH:27]=[CH:28][C:11]2=3)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl>ClCCl>[C:1]1([S:7]([N:10]2[CH2:16][CH2:15][CH:14]([NH2:17])[CH2:13][C:12]3[CH:25]=[CH:26][CH:27]=[CH:28][C:11]2=3)(=[O:8])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59400071tert-butyl 1-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-4-ylcarbamate

Product 1

HCID 59400108HCID 59400108, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1 tert-butyl 1-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-4-ylcarbamate in dichloromethane (2 mL) was added HCl (4 M in 1,4-dioxane, 2 mL, 8.0 mmol). The mixture was stirred at room temperature for 20 hours before being filtered and evaporated to dryness to yield 1-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-4-amine.

Workup

  1. filtrationbefore being filtered
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-17a00cab29c645b897368826039692cf
Source dataset
uspto-grants-2012_09
Patent number
US08273754B2

Reaction notes

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