tert-Butyl methyl ether → HCID 86618971, compound

HRID 2389617Notes

Reaction equation

HRID 2389617 reaction equation
[Cl:1][C:2]1[C:3]2[C:48]([F:49])=[CH:47][CH:46]=[C:45]([F:50])[C:4]=2[S:5][C:6]=1[C:7]([N:9]([CH2:25][C:26]1[CH:27]=[C:28]([C:34]2[CH:39]=[CH:38][C:37]([C:40](=[O:44])[N:41]([CH3:43])[CH3:42])=[CH:36][CH:35]=2)[CH:29]=[CH:30][C:31]=1[O:32][CH3:33])[CH:10]1[CH2:15][CH2:14][CH:13]([N:16](C)[C:17](=O)OC(C)(C)C)[CH2:12][CH2:11]1)=[O:8].CC(OC)(C)C>C(Cl)Cl>[ClH:1].[CH3:43][N:41]([CH3:42])[C:40]([C:37]1[CH:38]=[CH:39][C:34]([C:28]2[CH:29]=[CH:30][C:31]([O:32][CH3:33])=[C:26]([CH2:25][N:9]([CH:10]3[CH2:11][CH2:12][CH:13]([NH:16][CH3:17])[CH2:14][CH2:15]3)[C:7]([C:6]3[S:5][C:4]4[C:45]([F:50])=[CH:46][CH:47]=[C:48]([F:49])[C:3]=4[C:2]=3[Cl:1])=[O:8])[CH:27]=2)=[CH:35][CH:36]=1)=[O:44]

Participants

4

Reactant 2

HCID 15413tert-Butyl methyl etherHCID 59683577HCID 59683577, compound

Product 1

HCID 86618971HCID 86618971, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl carbamate 97 (250 mg, 0.34 mmol) is deprotected using Method F. The isolated salt is then dissolved in the minimum amount of DCM and added dropwise to cold (0° C.) TBME (25 mL). The resultant white precipitate is isolated by filtration and dried to afford the title compound.

Workup

  1. customThe resultant white precipitate is isolated by filtration
  2. customdried

Sources & evidence

ORD record
ord-0b284c4001844c8da021aad648006d24
Source dataset
uspto-grants-2012_09
Patent number
US08273747B2

Reaction notes

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