Methylamine → HCID 59683621, compound

HRID 2389647Notes

Reaction equation

HRID 2389647 reaction equation
[C:1]([O:5][C:6]([N:8]([CH3:49])[CH:9]1[CH2:14][CH2:13][CH:12]([N:15]([CH2:30][C:31]2[CH:32]=[C:33]([C:39]3[CH:44]=[CH:43][N:42]=[C:41]([C:45]([O:47]C)=O)[CH:40]=3)[CH:34]=[CH:35][C:36]=2[O:37][CH3:38])[C:16]([C:18]2[S:22][C:21]3[C:23]([F:28])=[CH:24][CH:25]=[C:26]([F:27])[C:20]=3[C:19]=2[Cl:29])=[O:17])[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:50][NH2:51]>CO>[Cl:29][C:19]1[C:20]2[C:26]([F:27])=[CH:25][CH:24]=[C:23]([F:28])[C:21]=2[S:22][C:18]=1[C:16]([N:15]([CH2:30][C:31]1[CH:32]=[C:33]([C:39]2[CH:44]=[CH:43][N:42]=[C:41]([C:45](=[O:47])[NH:51][CH3:50])[CH:40]=2)[CH:34]=[CH:35][C:36]=1[O:37][CH3:38])[CH:12]1[CH2:11][CH2:10][CH:9]([N:8]([CH3:49])[C:6](=[O:7])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2])[CH2:14][CH2:13]1)=[O:17]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 59683538HCID 59683538, compound

Product 1

HCID 59683621HCID 59683621, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A stirred solution of methyl ester 148 (30 mg, 0.05 mmol) in MeOH (2 mL) is treated with methylamine (1 mL, 40% solution in water) at RT. After 1 h, the reaction mixture is reduced in vacuo and the residue purified by column chromatography (75% EtOAc in heptane) to give the title compound.

Workup

  1. customthe residue purified by column chromatography (75% EtOAc in heptane)

Sources & evidence

ORD record
ord-d238887dec564d53a70c5d9fffa618e0
Source dataset
uspto-grants-2012_09
Patent number
US08273747B2

Reaction notes

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