Trifluoroacetic acid → HCID 68710392, compound

HRID 2389760Notes

Reaction equation

HRID 2389760 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([S:8][CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)[CH:5]=[CH:4][C:3]=1[N+:19]([O-:21])=[O:20].[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25]>ClCCl>[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25].[NH2:11][CH2:10][CH2:9][S:8][C:6]1[N:7]=[C:2]([NH2:1])[C:3]([N+:19]([O-:21])=[O:20])=[CH:4][CH:5]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59312893HCID 59312893, compound

Product 1

HCID 68710392HCID 68710392, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

6-[(2-Aminoethyl)thio]-3-nitropyridine-2-amine trifluoroacetate (Example 46A) is prepared in analogy to Example 40A from tert-butyl {2-[(6-amino-5-nitropyridin-2-yl)thio]ethyl}carbamate (Example 43A) (380 mg, 1.2 mmol) and trifluoroacetic acid (1.9 ml, 24 mmol) in dichloromethane (20 ml). 400 mg of the product are obtained.

Sources & evidence

ORD record
ord-10387ba169e24ca5ab28c2cc5a18e993
Source dataset
uspto-grants-2012_09
Patent number
US08273752B2

Reaction notes

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