Diisopropylethylamine → HCID 59313019, compound

HRID 2389841Notes

Reaction equation

HRID 2389841 reaction equation
FC(F)(F)C(O)=O.[NH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[N:18]=[C:17]([NH2:19])[C:16]([N+:20]([O-:22])=[O:21])=[CH:15][CH:14]=1.Cl[C:24]1[N:29]2[CH:30]=[CH:31][N:32]=[C:28]2[CH:27]=[C:26]([C:33]2[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][C:34]=2[Cl:40])[N:25]=1.CCN(C(C)C)C(C)C>C(O)(C)C>[Cl:40][C:34]1[CH:35]=[C:36]([Cl:39])[CH:37]=[CH:38][C:33]=1[C:26]1[N:25]=[C:24]([NH:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]2[N:18]=[C:17]([NH2:19])[C:16]([N+:20]([O-:22])=[O:21])=[CH:15][CH:14]=2)[N:29]2[CH:30]=[CH:31][N:32]=[C:28]2[CH:27]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 59312932HCID 59312932, compoundHCID 86641362HCID 86641362, compound

Product 1

HCID 59313019HCID 59313019, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
150 °C

Procedure

104 mg (0.32 mmol) of the amine (Example 57A) are introduced into 3 ml of isopropanol, 73.6 mg (0.25 mmol) of 5-chloro-7-(2,4-dichlorophenyl)imidazo[1,2-c]pyrimidine and 95.6 mg (0.74 mmol) of DIPEA are added, and the mixture is heated in a microwave at 150° C. for 2 h. Purification by preparative HPLC results in 96 mg (82% of theory) of the product.

Workup

  1. additionare added
  2. customPurification by preparative HPLC
  3. customresults in 96 mg (82% of theory) of the product

Sources & evidence

ORD record
ord-188b4be25675461c8bb4fadb429dbaf1
Source dataset
uspto-grants-2012_09
Patent number
US08273752B2

Reaction notes

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