Trimethylsilyl cyanide → (2-Phenylfuro[3,2-c]pyrazolo[1,5-a]pyridin-1-yl)acetonitrile

HRID 2389881Notes

Reaction equation

HRID 2389881 reaction equation
C[Si]([C:5]#[N:6])(C)C.[C:7]1([C:13]2[C:24]([CH2:25]O)=[C:16]3[C:17]4[CH:23]=[CH:22][O:21][C:18]=4[CH:19]=[CH:20][N:15]3[N:14]=2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>ClCCl.C(=O)([O-])O.[Na+]>[C:7]1([C:13]2[C:24]([CH2:25][C:5]#[N:6])=[C:16]3[C:17]4[CH:23]=[CH:22][O:21][C:18]=4[CH:19]=[CH:20][N:15]3[N:14]=2)[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

5

Reactant 2

HCID 82115Trimethylsilyl cyanideHCID 59179389(2-Phenylfuro[3,2-c]pyrazolo[1,5-a]pyridin-1-yl)methanol

Product 1

HCID 59179406(2-Phenylfuro[3,2-c]pyrazolo[1,5-a]pyridin-1-yl)acetonitrileYield 73%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolvent2×HCID 516892Sodium BicarbonateSolvent

Procedure

To a solution of boron trifluoride diethyl ether complex (460 μL, 3.63 mmol) and trimethylsilyl cyanide (645 μL, 4.84 mmol) in dichloromethane (12 mL) was added a solution of (2-phenylfuro[3,2-c]pyrazolo[1,5-a]pyridin-1-yl)methanol (320 mg, 1.21 mmol) in dichloromethane (12 mL) under ice-cooling and an argon atmosphere, and the mixture was stirred for 2 hr. The reaction solution was diluted with saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (ethyl acetate/hexane=10/90→50/50) to give the title compound (240 mg, yield 73%).

Workup

  1. temperaturecooling
  2. extractionthe mixture was extracted with ethyl acetate
  3. dry with materialThe extract was dried over anhydrous sodium sulfate
  4. customThe solvent was evaporated under reduced pressure
  5. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane=10/90→50/50)

Sources & evidence

ORD record
ord-d2489c6f33e342068a777baa59328844
Source dataset
uspto-grants-2012_09
Patent number
US08273761B2

Reaction notes

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