反应详情

A suspension of 47 g of 7-(4-bromobutoxy)-3,4-dihydrocarbostyril, 35 g of sodium iodide with 600 ml of acetonitrile was refluxed for 30 minutes. To this suspension was added 40 g of 1-(2,3-dichlorophenyl)piperazine and 33 ml of triethylamine and the whole mixture was further refluxed for 3 hours. After the solvent was removed by evaporation, the residue thus obtained was dissolved in chloroform, washed with water then dried with anhydrous magnesium sulfate. The solvent was removed by evaporation, and the residue thus obtained was recrystallized from ethanol twice, to yield 57.1 g of 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy}-3,4-dihydrocarbostyril.

1. temperaturewas refluxed for 30 minutes
2. temperaturethe whole mixture was further refluxed for 3 hours
3. customAfter the solvent was removed by evaporation
4. customthe residue thus obtained
5. washwashed with water
6. dry with materialthen dried with anhydrous magnesium sulfate
7. customThe solvent was removed by evaporation
8. customthe residue thus obtained
9. customwas recrystallized from ethanol twice