反应详情

温度

60 °C

A solution of 4-(methylsulfonyl)-2-nitro-1-vinylbenzene (Intermediate 121; 3.60 g; 15.8 mmol) in AcOH (100 mL) was treated with a solution of iron (15.9 g; 285 mmol) in AcOH (20 ml) and the reaction mixture was stirred at 60° C. for 1 h. EtOAc was added and the solution was filtered, the solvents removed under reduced pressure. The residue was taken up in EtOAc, washed with a sat. NaHCO3 solution in water, then with brine. The organic layer was dried, filtered and concentrated to give the title compound.

1. filtrationthe solution was filtered
2. customthe solvents removed under reduced pressure
3. washwashed with a sat. NaHCO3 solution in water
4. customThe organic layer was dried
5. filtrationfiltered
6. concentrationconcentrated