反应详情

温度

120 °C

A mixture of 2-bromo-4-chlorophenol (250 mg; 1.21 mmol) and ethyl-2-bromoisobutyrate (450 μl; 3.0 mmol) in DMF (5 mL) was treated with K2CO3 (250 mg, 1.81 mmol) and heated at 120° C. for 4.5 hours. Water was added and the reaction mixture was extracted 3 times with EtOAc. The combined organic phases were dried over MgSO4, filtered, concentrated and purified by flash column chromatography (silica), eluting with heptane containing increasing amounts of EtOAc. The title compound was obtained as a yellow sticky solid (320 mg; 83%).

1. extractionthe reaction mixture was extracted 3 times with EtOAc
2. dry with materialThe combined organic phases were dried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated
5. custompurified by flash column chromatography (silica)
6. washeluting with heptane containing
7. temperatureincreasing amounts of EtOAc