3-Bromopyridine → HCID 56594384, compound

HRID 2390330Notes

Reaction equation

HRID 2390330 reaction equation
C([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[CH:17])(C)(C)C.Br[C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:5])=[O:18])=[C:10]([C:16]#[C:17][C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)[CH:11]=1

Participants

3

Reactant 2

HCID 122863-BromopyridineHCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetate2×

Product 1

HCID 56594384HCID 56594384, compound

Procedure

Following the general method as outlined in Example 10, starting from tert-butyl(4-chloro-2-ethynylphenoxy)acetate (Intermediate 3) and 3-bromopyridine (Fluka), the title compound was obtained as an off-white solid after purification by preparative HPLC.

Sources & evidence

ORD record
ord-e586d318626040668337f48cc8d8004d
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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