Methylamine → Benzenamine, N-methyl-2-nitro-4-(trifluoromethyl)-

HRID 2390485Notes

Reaction equation

HRID 2390485 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[CH3:15][N:16]1CCCC1=O.CN>O>[CH3:15][NH:16][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13]

Participants

5

Reactant 3

HCID 6329MethylamineHCID 13387N-methyl-2-pyrrolidoneHCID 677784-Fluoro-3-nitrobenzotrifluoride

Product 1

HCID 88405Benzenamine, N-methyl-2-nitro-4-(trifluoromethyl)-

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of 2.09 g of 4-fluoro-3-nitrobenzo trifluoride and 20 ml of N-methylpyrrolidone was added 2.33 g of a 40% methylamine aqueous solution under ice cool, and the mixture was heated up to room temperature and stirred for 1 hour. Water was poured, and the deposited precipitate was filtrated, then, washed with water, then, dried under reduced pressure to obtain 2.0 g of N-methyl-2-nitro-4-trifluoromethylaniline.

Workup

  1. temperaturecool
  2. filtrationthe deposited precipitate was filtrated
  3. washwashed with water
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-4020ab7e4c9d4ddbaeb6be6cf578dde8
Source dataset
uspto-grants-2012_09
Patent number
US08273764B2

Reaction notes

Loading…