Propylamine → HCID 7123352, compound

HRID 2390493Notes

Reaction equation

HRID 2390493 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].C[N:16]1C[CH2:19][CH2:18][C:17]1=O.C(N)CC>O>[CH2:17]([NH:16][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13])[CH2:18][CH3:19]

Participants

5

Reactant 3

HCID 7852PropylamineHCID 13387N-methyl-2-pyrrolidoneHCID 677784-Fluoro-3-nitrobenzotrifluoride

Product 1

HCID 7123352HCID 7123352, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of 5.23 g of 4-fluoro-3-nitro-benzo trifluoride and 25 ml of N-methylpyrrolidone was added 3.69 g of n-propylamine under ice cool, and the mixture was stirred for 1 hour at room temperature. The reaction mixture was poured into water, and the deposited solid was collected by filtration. This solid was washed with water, then, dried under reduced pressure to obtain 2.78 g of N-propyl-2-nitro-4-trifluoromethylaniline.

Workup

  1. temperaturecool
  2. filtrationthe deposited solid was collected by filtration
  3. washThis solid was washed with water
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-f87e31ce157e4744a39d79e6e225b6bc
Source dataset
uspto-grants-2012_09
Patent number
US08273764B2

Reaction notes

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