反应详情

To a solution of 4-bromo-3-(bromomethyl)benzonitrile (0.95 g, 3.46 mmol) in DMF (13.40 ml) was added thiomorpholine (0.417 ml, 4.15 mmol) and potassium carbonate (0.573 g, 4.15 mmol). The reaction mixture was allowed to stir at RT overnight. The reaction mixture was poured onto water and extracted with EtOAc (×2). The organic extractions were combined, washed with brine (×3), dried (MgSO4) and evaporated to give a yellow oil. This was purified by flash silica chromatography (Biotage column) (eluent=25% ether/isohexane) to give the sub-title compound as a colourless oil. Yield: 0.951 g

1. additionThe reaction mixture was poured onto water
2. extractionextracted with EtOAc (×2)
3. extractionThe organic extractions
4. washwashed with brine (×3)
5. dry with materialdried (MgSO4)
6. customevaporated
7. customto give a yellow oil
8. customThis was purified by flash silica chromatography (Biotage column) (eluent=25% ether/isohexane)