反应详情

step 4—A mixture of 84 (0.131 g, 0.29 mmol) and Pd(OH)2 (20% wt. on carbon, 0.100 g) in EtOAc (20 mL) and MeOH (20 mL) in a Parr bottle at RT was shaken under 40 psi hydrogen atmosphere for 45 min. The catalyst was filtered and the filtrate was concentrated to afford 0.093 g (66%) of N-(4-{2-[2-amino-5-tert-butyl-3-(2-methoxy-pyridin-3-yl)-phenyl]-ethyl}-phenyl)-methanesulfonamide (86) as an off-white solid.

1. filtrationThe catalyst was filtered
2. concentrationthe filtrate was concentrated