反应详情

To xylene (2 mL) suspension of 0.10 g of 2-(1-benzothiophen-5-yl)malonic acid was added 4 mg of p-toluenesulfonic acid monohydrate, which was then refluxed for 1 hour. The solvent was distilled off under reduced pressure, and to the resultant residue was added cyclohexane. The precipitate was collected by filtration to provide 0.08 g of 2-(1-benzothiophen-5-yl)acetic acid as white solid form.

1. temperaturewas then refluxed for 1 hour
2. distillationThe solvent was distilled off under reduced pressure
3. additionto the resultant residue was added cyclohexane
4. filtrationThe precipitate was collected by filtration