Chloride → HCID 178426315, compound

HRID 2390995Notes

Reaction equation

HRID 2390995 reaction equation
[C:1]([NH2:9])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=C[CH:3]=1.[NH:10]1C=CC=N1.[Cl:15][C:16]1[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][C:17]=1[C:18]([NH:20][C@H:21]1[CH2:26][CH2:25][C@H:24]([CH:27]=O)[CH2:23][CH2:22]1)=[O:19].Cl.COC([C@H]1CC[C@H](N)CC1)=O.[Cl-]>>[Cl:15][C:16]1[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][C:17]=1[C:18]([NH:20][C@H:21]1[CH2:26][CH2:25][C@H:24]([CH2:27][NH:10][C:1]2[C:2]([CH3:3])=[CH:7][CH:6]=[CH:5][N:9]=2)[CH2:23][CH2:22]1)=[O:19]

Participants

6

Reactant 5

HCID 312ChlorideHCID 1048PyrazoleHCID 2331BenzamideHCID 178501210HCID 178501210, compoundHCID 178520978HCID 178520978, compound

Product 1

HCID 178426315HCID 178426315, compound

Procedure

The compounds of the following tabulated Examples (Table 1) are prepared by a similar method to that of Example 1 using the appropriate benzamide or pyrazole starting materials (prepared analogously to trans-2-chloro-N-(4-formyl-cyclohexyl)-5-trifluoromethyl-benzamide from trans-4-amino-cyclohexylcarboxylic acid methyl ester hydrochloride and the appropriate benzoly chloride) and the appropriate amine.

Sources & evidence

ORD record
ord-ff20b07c643149908f70502a13f06b38
Source dataset
uspto-grants-2012_09
Patent number
US08273900B2

Reaction notes

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