反应详情

25 mg methylamine was added to 200 mg 2-phenoxycarbonylamino-6,7-dihydro-4H-thiazolo-[5,4-c]pyridine-5-carboxylic acid tert-butyl ester in 25 mL DMF. The reaction was stirred for 12 h at RT, diluted with water and extracted with ethyl acetate. The organic layer was washed with brine solution and concentrated. The residue was purified by column chromatographie (silica gel, eluent: 40% ethylacetate in hexane) to give 151 mg of desired product. (M+H)+: 313

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with brine solution
3. concentrationconcentrated
4. customThe residue was purified by column chromatographie (silica gel, eluent: 40% ethylacetate in hexane)