Hydrochloric Acid → 1-methyl-1H-1,2,3-triazole-4-carboxylic acid

HRID 2391125Notes

Reaction equation

HRID 2391125 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([O:9]CC)=[O:8])[N:4]=[N:3]1.[OH-].[Na+].Cl>CO>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[N:4]=[N:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21278002Ethyl 1-methyl-1H-1,2,3-triazole-4-carboxylate

Product 1

HCID 217664121-methyl-1H-1,2,3-triazole-4-carboxylic acidYield 50%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using ethyl 1-methyl-1H-1,2,3-triazole-4-carboxylate (1.48 g, 9.54 mmol), methanol (22 mL), 1N sodium hydroxide (15 mL) and 1N hydrochloric acid (15 mL) as starting materials and in the same manner as in Reference Example 12, the title compound (605 mg, 50%) was obtained as a white powder.

Sources & evidence

ORD record
ord-af1c90b250204a2e9a71d79db743b366
Source dataset
uspto-grants-2012_09
Patent number
US08273741B2

Reaction notes

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