Potassium Carbonate → HCID 57505493, compound

HRID 2391228Notes

Reaction equation

HRID 2391228 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([NH:11][C:12]([CH:14]3[CH2:16][CH2:15]3)=[O:13])[N:10]=2)[N:7]=1.[CH3:17][N:18]1[C:22]2[CH:23]=[CH:24][C:25]([OH:27])=[CH:26][C:21]=2[N:20]=[C:19]1[CH3:28].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:17][N:18]1[C:22]2[CH:23]=[CH:24][C:25]([O:27][C:2]3[CH:3]=[CH:4][C:5]4[N:6]([CH:8]=[C:9]([NH:11][C:12]([CH:14]5[CH2:16][CH2:15]5)=[O:13])[N:10]=4)[N:7]=3)=[CH:26][C:21]=2[N:20]=[C:19]1[CH3:28]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 6585351H-Benzimidazol-5-ol,1,2-dimethyl-(9CI)HCID 57386058N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide

Product 1

HCID 57505493HCID 57505493, compoundYield 28.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide (254 mg, 0.774 mmol), 1,2-dimethyl-1H-benzimidazole-5-ol (163 mg, 1.06 mmol), potassium carbonate (267 mg, 1.94 mmol) and N,N-dimethylformamide (3.0 mL) as starting materials and in the same manner as in Example 95, the title compound (79 mg, 28%) was obtained as a white powder.

Sources & evidence

ORD record
ord-adbfd20d4d1a4813b7a0996f21379d6c
Source dataset
uspto-grants-2012_09
Patent number
US08273741B2

Reaction notes

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