Potassium Carbonate → N-{6-[(2-methyl-1,3-benzothiazol-6-yl)oxy]imidazo[1,2-b]pyridazin-2-yl}cyclopropanecarboxamide

HRID 2391241Notes

Reaction equation

HRID 2391241 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([NH:11][C:12]([CH:14]3[CH2:16][CH2:15]3)=[O:13])[N:10]=2)[N:7]=1.[CH3:17][C:18]1[S:19][C:20]2[CH:26]=[C:25]([OH:27])[CH:24]=[CH:23][C:21]=2[N:22]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:17][C:18]1[S:19][C:20]2[CH:26]=[C:25]([O:27][C:2]3[CH:3]=[CH:4][C:5]4[N:6]([CH:8]=[C:9]([NH:11][C:12]([CH:14]5[CH2:16][CH2:15]5)=[O:13])[N:10]=4)[N:7]=3)[CH:24]=[CH:23][C:21]=2[N:22]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 7593042-Methyl-1,3-benzothiazol-6-olHCID 57386058N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide

Product 1

HCID 57505503N-{6-[(2-methyl-1,3-benzothiazol-6-yl)oxy]imidazo[1,2-b]pyridazin-2-yl}cyclopropanecarboxamideYield 44%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide (309 mg, 0.942 mmol), 2-methyl-1,3-benzothiazole-6-ol (250 mg, 1.51 mmol), potassium carbonate (390 mg, 2.83 mmol) and N,N-dimethylformamide (4.0 mL) as starting materials and in the same manner as in Example 95, the title compound (151 mg, 44%) was obtained as a pale-yellow powder.

Sources & evidence

ORD record
ord-41a031445082469a9dd506e8b089e1f2
Source dataset
uspto-grants-2012_09
Patent number
US08273741B2

Reaction notes

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