Benzyl Bromide → HCID 86686495, compound

HRID 239134Notes

Reaction equation

HRID 239134 reaction equation
[CH2:1]([Br:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][C:10]1[O:14][C:13]([C:15]2[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=2)=[N:12][CH:11]=1>CC(C)=O>[Br-:8].[CH2:1]([N+:18]1[CH:17]=[CH:16][C:15]([C:13]2[O:14][C:10]([CH3:9])=[CH:11][N:12]=2)=[CH:20][CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7498Benzyl BromideHCID 24971853HCID 24971853, compound

Product 1

HCID 86686495HCID 86686495, compoundYield 92.3%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

141 g benzylbromide was added to 66 g 4-(5-methyl-oxazol-2-yl)-pyridine in 1.5 L acetone. The mixture was refluxed over night. The precipitate was filtered to give 126 g of the desired product. Rf: 0.00 (petrolether/ethyl acetate=1/1), (M+H)+: 252

Workup

  1. temperatureThe mixture was refluxed over night
  2. filtrationThe precipitate was filtered

Sources & evidence

ORD record
ord-2b228c77cf7f4ad3a30779f0ec6a696a
Source dataset
uspto-grants-2014_02
Patent number
US08642774B2

Reaction notes

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