Hydrochloric Acid → HCID 89611789, compound

HRID 239139Notes

Reaction equation

HRID 239139 reaction equation
Br.C(OC([N:9]1[CH2:14][CH2:13][N:12]([C:15]2[O:16][CH2:17][CH2:18][N:19]=2)[CH2:11][CH2:10]1)=O)(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[ClH:20].[O:16]1[CH2:17][CH2:18][N:19]=[C:15]1[N:12]1[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89611810HCID 89611810, compound

Product 1

HCID 89611789HCID 89611789, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

430 mg 4-(4,5-dihydro-oxazol-2-yl)-piperazine-1-carboxylic acid tert-butyl esterhydrobromide was stirred in 5 mL 4 M HCl solution in dioxane for 20 min. The mixture was filtered to give 165 mg of the desired product. Rt: 0.88 min (method B), (M+H)+: 156

Workup

  1. filtrationThe mixture was filtered

Sources & evidence

ORD record
ord-7ba89c2ab0f74374b873933b9cd922e7
Source dataset
uspto-grants-2014_02
Patent number
US08642774B2

Reaction notes

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